Structures of Capsid and Capsid-Associated Tegument Complex Inside the Epstein-Barr Virus

As the first discovered human cancer virus, Epstein-Barr virus (EBV) causes Burkitt's lymphoma and nasopharyngeal carcinoma. Isolating virions for determining high-resolution structures has been hindered by latency—a hallmark of EBV infection—and atomic are thus available only recombinantly expressed proteins. in present study, symmetry relaxation subparticle reconstruction, we have determined near-atomic-resolution capsid with an asymmetrically attached DNA-translocating portal capsid-associated tegument complexes from cryogenic electron microscopy images just 2,048 obtained chemical induction.